Chronically elevated levels of fatty acids-FA can cause beta cell death in vitro.Beta cells vary in their individual susceptibility to FA-toxicity.Rat beta cells were previously shown to better resist FA-toxicity in conditions that increased triglyceride formation or mitochondrial and peroxisomal FA-oxidation, possibly reducing cytoplasmic levels o
Operational assimilation of ASCAT surface soil wetness at the Met Office
Currently, no extensive, near real time, global soil moisture observation network exists.Therefore, the Met Office global soil moisture analysis scheme has instead used observations of screen temperature and humidity.A number of new space-borne remote sensing systems, operating at microwave frequencies, have been developed that provide a more direc
Addressing injecting related risks among people who inject both opioids and stimulants: Findings from an Australian survey of people who inject drugs
Background: Opioids and stimulants are the most commonly injected illicit drugs worldwide and in Australia.While some people who inject drugs (PWID) prefer either opioids or stimulants, others regularly use both opioids and stimulants.Limited available research indicates that those who use opioids and stimulants together, either in combination or a
The Warm Temperament (Mizaj) as a Predictors of Anxiety Disorder among Participants in the Kerman Coronary Artery Disease Risk Factors Study (KERCADRS)
Anxiety disorders are the most common mental disorders in communities.This cross-sectional study assessed the relationship between temperament and other demographic characteristics of participants with anxiety.It also determined the predictors of anxiety disorder among this cohort.This cross-sectional study was conducted in Kerman, Iran from 11 Mar
Psychotherapy and medication management strategies for obsessive-compulsive disorder
Kelda H Walsh, Christopher J McDougleDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USAAbstract: Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder.While medication and psychotherapy advances have been very helpful to patients, many patients do not respond adequately to initial trials of serotonerg